TF IsotopeTracers

MRI RFP

http://www.nsf.gov/pubs/2013/nsf13517/nsf13517.htm

Highlights.

"MRI is not used to buy a suite of insturments to outfit research laboratories/facilities or be used to conduct independent research activities simultaneously".

"MRI is used for a single insturment or when combined serves as an integrated instrument."

The photon flux monitor when combined with the rabbit will be an instrument for both isotope production and PAA analysis research. The tool will have inter-disciplinary uses ranging from engineering to archeology.

Track1

Acquisition of a single instrument

Track2

development of a single instrument or for equipment that when combined serves as an integrated instrument.

We will be track 2. The combined equipment will be an integrated instrument for the production of Isotopes to be used in research and industry. The devise will also be an instrument for PAA analysis.

Proposal

Purpose

In June of 2012, the Idaho Accelerator Center received a grant from the state of Idaho as part of the Idaho Global Entrepreneurial Mission (IGEM) program. One of the proposed objectives was to research the use of an electron accelerator to the produce Copper isotopes to be used in medical diagnostic procedures. Preliminary results of the work sponsored by this research have indicated that the production of Copper isotopes strongly depends on the alignment of incident radiation to the sample. While a sample size of 2 cm may produce the highest number of isotopes per volume, a missalignment of more than a centimeter may reduce the amount of isotopes produced by a factor of at least two. A strong need now exists for a system to monitor the spatial distribution of the photons used to irradiate the samples. Based on these results, we propose the development of an irradiation instrument, that qualifies for the MRI category "Track 2", to be used for isotope production and PAA analysis.

The proposed instrument will be composed of a photon beam monitoring system and a sample conveyor. Support from this MRI will be used to construct the photon monitoring system. Matching support from the IGEM project will be used for the sample conveyor system. The conveyor, commonly referred to as a rabbit, will transport samples into the irradiation region and then to a shielded container (lead pig) after irradiation. The transportation system is a necessity due to the high activity isotopes that may be produced. When used as an instrument for PAA, the transportation system will eliminate the step of shutting the accelerator off in order to change to the control sample thereby risking a change in the experimental conditions whose uniformity is essential for meaningful measurements. Once calibrated, the photon monitoring system would allow users to irradiate sample with a known amount of radiation.

The proposed instruments ability to enhance the production of copper isotopes for medical diagnostic tests is only one potential use. Isotope production in the US is a $$$ busines..

Paragraph of the instruments impact on the production of isotopes.

Using the instrument for PAA and the large potential user base.

The University of Missouri's Research Reactor is a current producer of medical isotopes with a total operating budget o

Talking points

1.) The accelerator "Jack" is an instrument for PAA and isotope production

2.) Isotope production impact on other areas of research (medical, fracking, underground pipelines, spikants for homeland security)

3.) Inter organizational use of PAA ( Geology, Archeology, certification for coffee origins....)

4.) Impact of Photon Flux monitoring for PAA analysis

5.) Device will train accelerator physicists, nuclear chemists, ...

Budget

Equipment list

two steps

1.) purchase 16, single crystal detectors from http://www.npl.co.uk/upload/pdf/091104_nuc_galbiati.pdf. These will serve as monitors distributed symmetrically around the beam line and used to steer the electron beam until equal photon rates are observed => centered photon beam.

2.) A wire tungsten wire coated with diamond will sweep through the photon beam in the location of the target to measure the photon flux.

get http://www.npl.co.uk/upload/pdf/091104_nuc_galbiati.pdf to build a pixelated 3 x 3 cm detector with .5 x .5 cm size pixels (36 pixels)

OR if the photon flux is too high construct a wire array.

Cost	Device	Purpose
50,000	BPMs	4 electron beam position monitors
20,000	16, CVD Diamond detector	Off the shelf single crystal single pixel detector pg 49 in[ http://www.npl.co.uk/upload/pdf/091104_nuc_galbiati.pdf]
10,000	20 , 5 x 5 mm^2 CVD films	films for pixel detector array or wire (tungsten coated with diamond) scanner
10,000	Circuitry	PCB board, connectors, and single crystal mounting by external vendor
30,000	beam time	3 weeks of beam time to test device and measure performance
$28,000	DAQ	VME based DAQ system with EPICs monitoring, 32 channel ADC ($6k), ROC($3k), MiniCrate($4k), Server ($2k), Tigger supervisor ($3k), NIM Discriminator /Trigger/ECL output module ($10k)
$10k Cost Share	Beam Line components	Steering coils ($1k), power supplies ($4k), and Beam line components($5k) to install BPMs
$160k Cost Share	Rabbit	sample conveyor system from IGEM grant

Proposed Budget

$148k + $160k (Cost share) = $308k

References

Nitrogen tracers: N-15 is rare. If you dope nitrogen sources with it you can see where the leak into environment. This is a stable tracer so it would be able to monitor long time plume expansions.

Catchment hydrology

Review of Diamond detectors

http://www.ifh.de/~akg/phys/tapper.pdf

Simulations

http://www.osti.gov/energycitations/product.biblio.jsp?query_id=1&page=0&osti_id=20658046

High Flux MeV photon profiler

http://accelconf.web.cern.ch/accelconf/p99/PAPERS/WEA90.PDF

http://ieeexplore.ieee.org/ielx5/5379507/5398121/05398374.pdf?tp=&arnumber=5398374&isnumber=5398121

CVD Diamond film

Film Vendor only

http://www.e6cvd.com/cvd/page.jsp?pageid=415

Alemeda Applied Sciences Corporation

http://www.aasc.net/drds http://www.aasc.net/media/DRD-AppNote.pdf

Diamond x-ray view screen http://www.diamond-materials.com/EN/products/cvd_for_xray/fluorescence_beam_monitors.htm

http://www.npl.co.uk/upload/pdf/091104_nuc_galbiati.pdf

NIM paper from 2002

http://144.206.159.178/ft/787/47160/14168748.pdf

Diamond Detectors LtD (Vendor for single crystal Chip on Board Package)

http://www.npl.co.uk/upload/pdf/091104_nuc_galbiati.pdf

Medical isotopes

2013 DOE Medical Isotope program budget and info

http://science.energy.gov/~/media/budget/pdf/sc-budget-request-to-congress/fy-2013/Cong_Budget_2013_IsoptopeProductionandDistributionProgramFunding.pdf

2010 Talk on Future Isotope needs in medicine and industry

http://www.nscl.msu.edu/~mantica/radio-frib/runde-acsboston.pdf

Need Mo-99, Tc-99m, I-131, I-125, Cu-67, At-211, Ac-225, Bi-213, Am-241, Gd-148, Sr-90, Pm-147

A big isotope supplier is Eckert & Ziegler

http://www.ezag.com/fileadmin/ezag/user-uploads/pdf/analyses-englisch/concord_e_01.pdf

2009 Medical Isotope industry & trade study

http://www.usitc.gov/publications/332/ITS-1.pdf

Simulation Results

Photon flux (assuming 40 MeV electrons hitting 4 mm thick W converter and then Zn target

Effect of beam shift on Zn foils (experiment)

Effect of beam shift on Zn target (simulations)