Difference between revisions of "TF Actinium"

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=Current production facilities=
 
=Current production facilities=
  
Ac-225 (Cancer Therapy) BNL (BLIP), LANL (IPF)
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==Ac-225==
  
Ac-227 (Cancer Therapy) ORNL (HFIR)
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An alpha emitter for Cancer Therapy
  
Ac-225 (Cancer Therapy) ORNL
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made at : BNL (BLIP), LANL (IPF), ORNL
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 +
 
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https://phys.org/news/2018-06-scientists-actinium-rare-medical-radioisotope.html
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DOE IP is focused on Ac-225, but its production via limited to the amount of  Th-229 on hand (so called Thorium cow).  So we are also pursuing accelerator based production (mostly proton machines, but also some photo-nuclear reactions).  The proton machines also generates comparable amount of  Ac-227 which is problematic due to its long lifetime.
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One could use an electron machine
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Single neutron knockout of Ra-226 goes to Ra-225 which decays to Ac-225 after 14 days most of the time but 0.026 of the time it alpha decays.  Ac-225 is an alpha emitter with a half life of 29 hours.
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==Ac-227 (Cancer Therapy)==
 +
ORNL (HFIR)
 +
 
 +
Ac-227 is presently produced by the DOE IP to be incorporated into the Bayer Xofigo drug, where the mode of interest is that Ac-227 -> Ra-226 which eventually emits an alpha (Ra-226 generators).  so the beta emission is not what drives its use as a cancer therapy, the resulting alpha from the Ra-226 is what makes it useful.
  
  
  
 
[[TF_Isotopes]]
 
[[TF_Isotopes]]

Latest revision as of 18:45, 30 July 2020

TF_Isotopes


Current production facilities

Ac-225

An alpha emitter for Cancer Therapy

made at : BNL (BLIP), LANL (IPF), ORNL


https://phys.org/news/2018-06-scientists-actinium-rare-medical-radioisotope.html

DOE IP is focused on Ac-225, but its production via limited to the amount of Th-229 on hand (so called Thorium cow). So we are also pursuing accelerator based production (mostly proton machines, but also some photo-nuclear reactions). The proton machines also generates comparable amount of Ac-227 which is problematic due to its long lifetime.

One could use an electron machine


Single neutron knockout of Ra-226 goes to Ra-225 which decays to Ac-225 after 14 days most of the time but 0.026 of the time it alpha decays. Ac-225 is an alpha emitter with a half life of 29 hours.

Ac-227 (Cancer Therapy)

ORNL (HFIR)

Ac-227 is presently produced by the DOE IP to be incorporated into the Bayer Xofigo drug, where the mode of interest is that Ac-227 -> Ra-226 which eventually emits an alpha (Ra-226 generators). so the beta emission is not what drives its use as a cancer therapy, the resulting alpha from the Ra-226 is what makes it useful.


TF_Isotopes