Difference between revisions of "TF Antimony"
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Theradiagnostic is an therapy with companion atoms. One atom serves as the radiological therapy and the other atom emits radiation that is detectable to a diagnostic device. For example Sb-119 emits low energy auger electrons to kill cancer cells while Sb-117 beta decays emitting a positron that annihilates and emits two 511 photons that are detectable by a PET scanner. The half life of Sb-117 is less than 3 hours and the half life of Sb-119 is 38 hours. | Theradiagnostic is an therapy with companion atoms. One atom serves as the radiological therapy and the other atom emits radiation that is detectable to a diagnostic device. For example Sb-119 emits low energy auger electrons to kill cancer cells while Sb-117 beta decays emitting a positron that annihilates and emits two 511 photons that are detectable by a PET scanner. The half life of Sb-117 is less than 3 hours and the half life of Sb-119 is 38 hours. | ||
| + | ==Competition== | ||
| + | |||
| + | ===Cyclotrons=== | ||
| + | |||
| + | |||
| + | |||
| + | Sn-119 +p -> Sb-119 + n | ||
| + | |||
| + | Separating Sn-119 from Sb-119 reqires more than a half life of Sb-119 | ||
| + | |||
| + | as a result you get 0.001 Ci in 10 days | ||
| + | |||
| + | |||
| + | ===Proton irradiation=== | ||
| + | Sb-121 + p -> Te-119m + 3n -> Sb-119 | ||
| + | |||
| + | Sb-123 + p -> Te-119m + 5n -> Sb-119 | ||
| + | |||
| + | 4 day halflife for Te-119m to decay to Sb-119 | ||
| + | |||
| + | 0.001 Ci in 45 days | ||
=Separating Sb from Te= | =Separating Sb from Te= | ||
Revision as of 23:32, 31 July 2020
Antiomony(Sb)
Tellurium(Te) to Antimony(Sb)
A pure Tellurium foils is immersed in a bremstraahlung beam to eject a proton from Te-120 leaving the Antimony isotope Se-119.
\gamma + Te-120 -> Sb-119 + p
Yield Problem: Te-119 is only 0.1% of the natural abundance. Highest natural abundance is Te-126 at 19%, then Te-125 at 7%, Te-124 at 5%, Te-122 at 2.5%, Te-123 at 1%.
Melting point of foils is 450 C
Sb-119 decays by emitting K-edge and conversion electrons, collectively called Auger electrons.
Sb-117 is a PET analog => in 2 hrs Sb-117 decays emitting a positron that will annihilate and produce two 511 keV photons for a PET imager to detect.
Theradiagnostic is an therapy with companion atoms. One atom serves as the radiological therapy and the other atom emits radiation that is detectable to a diagnostic device. For example Sb-119 emits low energy auger electrons to kill cancer cells while Sb-117 beta decays emitting a positron that annihilates and emits two 511 photons that are detectable by a PET scanner. The half life of Sb-117 is less than 3 hours and the half life of Sb-119 is 38 hours.
Competition
Cyclotrons
Sn-119 +p -> Sb-119 + n
Separating Sn-119 from Sb-119 reqires more than a half life of Sb-119
as a result you get 0.001 Ci in 10 days
Proton irradiation
Sb-121 + p -> Te-119m + 3n -> Sb-119
Sb-123 + p -> Te-119m + 5n -> Sb-119
4 day halflife for Te-119m to decay to Sb-119
0.001 Ci in 45 days
Separating Sb from Te
use anion-exchange chromatographic
Radiochemical separation of antimony and tellurium in isotope production and in radionuclide generators, D. Downs & D. A. Miller, Journal of Radioanalytical and Nuclear Chemistry volume 262, Article number: 241 (2004)
References
Large Scale Production of 119mTe and 119Sb for Radiopharmaceutical Applications ,Kevin T. Bennett, Sharon E. Bone, Andrew C. Akin, Eva R. Birnbaum, Anastasia V. Blake, Mark Brugh, Scott R. Daly, Jonathan W. Engle, Michael E. Fassbender, Maryline G. Ferrier, Stosh A. Kozimor*, Laura M. Lilley, Christopher A. Martinez, Veronika Mocko, Francois M. Nortier, Benjamin W. Stein, Sara L. Thiemann, and Christiaan Vermeulen, Cite this: ACS Cent. Sci. 2019, 5, 3, 494–505 Publication Date:February 25, 2019 https://doi.org/10.1021/acscentsci.8b00869
https://pubs.acs.org/doi/10.1021/acscentsci.8b00869
Accelerator based Production of Auger-Electron-emitting Isotopes for Radionuclide Therapy Helge ThisgaardR, PhD-theis, pg 22; Thesis may have led to this publication Thisgaard H.; Jensen M. Production of the Auger emitter 119Sb for targeted radionuclide therapy using a small PET-cyclotron. Appl. Radiat. Isot. 2009, 67, 34–38.
The Paradox of Using Radionuclides To Treat Disease, Thomas E. Albrecht-Schmitt, ACS Cent Sci. 2019 Mar 27; 5(3): 383–385
Anion exchange separation of tin, antimony and tellurium, GilbertW. SmithS.A.Reynolds , Analytica Chimica Acta
Volume 12, 1955, Pages 151-153