Difference between revisions of "TF Actinium"
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=Current production facilities= | =Current production facilities= | ||
| − | Ac-225 | + | ==Ac-225== |
| − | + | An alpha emitter for Cancer Therapy | |
| − | Ac-225 (Cancer Therapy) ORNL | + | made at : BNL (BLIP), LANL (IPF), ORNL |
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| + | https://phys.org/news/2018-06-scientists-actinium-rare-medical-radioisotope.html | ||
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| + | DOE IP is focused on Ac-225, but its production via limited to the amount of Th-229 on hand (so called Thorium cow). So we are also pursuing accelerator based production (mostly proton machines, but also some photo-nuclear reactions). The proton machines also generates comparable amount of Ac-227 which is problematic due to its long lifetime. | ||
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| + | One could use an electron machine | ||
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| + | Single neutron knockout of Ra-226 goes to Ra-225 which decays to Ac-225 after 14 days most of the time but 0.026 of the time it alpha decays. Ac-225 is an alpha emitter with a half life of 29 hours. | ||
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| + | ==Ac-227 (Cancer Therapy)== | ||
| + | ORNL (HFIR) | ||
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| + | Ac-227 is presently produced by the DOE IP to be incorporated into the Bayer Xofigo drug, where the mode of interest is that Ac-227 -> Ra-226 which eventually emits an alpha (Ra-226 generators). so the beta emission is not what drives its use as a cancer therapy, the resulting alpha from the Ra-226 is what makes it useful. | ||
[[TF_Isotopes]] | [[TF_Isotopes]] | ||
Latest revision as of 18:45, 30 July 2020
Current production facilities
Ac-225
An alpha emitter for Cancer Therapy
made at : BNL (BLIP), LANL (IPF), ORNL
https://phys.org/news/2018-06-scientists-actinium-rare-medical-radioisotope.html
DOE IP is focused on Ac-225, but its production via limited to the amount of Th-229 on hand (so called Thorium cow). So we are also pursuing accelerator based production (mostly proton machines, but also some photo-nuclear reactions). The proton machines also generates comparable amount of Ac-227 which is problematic due to its long lifetime.
One could use an electron machine
Single neutron knockout of Ra-226 goes to Ra-225 which decays to Ac-225 after 14 days most of the time but 0.026 of the time it alpha decays. Ac-225 is an alpha emitter with a half life of 29 hours.
Ac-227 (Cancer Therapy)
ORNL (HFIR)
Ac-227 is presently produced by the DOE IP to be incorporated into the Bayer Xofigo drug, where the mode of interest is that Ac-227 -> Ra-226 which eventually emits an alpha (Ra-226 generators). so the beta emission is not what drives its use as a cancer therapy, the resulting alpha from the Ra-226 is what makes it useful.